Changing demands, expectations and structures in our society, as well as developments within the healthcare system, are constantly placing new demands on future physicians. The influence of digitalization, the immense increase in knowledge in medicine and options that change almost daily as a result also influence expectations of the medical profession. We are convinced that these challenges must already be taken into account and specifically addressed in medical training. The Düsseldorf Curriculum of Medicine combines proven and new concepts with the aim of optimally preparing students for the medical profession of tomorrow.